Frank Goossens on "Autoptimize breaks WP Online Contracts"

yes, using the API you can, there's example code in autoptimize_helper.php_example;

assuming the posts with a contract have "contract" in the URL, this code will exclude those pages from optimizatoin:

add_filter('autoptimize_filter_noptimize','beloved_ao_noptimize',10,0);
function beloved_ao_noptimize() {
	if (strpos($_SERVER['REQUEST_URI'],'contract')!==false) {
		return true;
	} else {
		return false;
	}
}

hope this helps,
frank